Program

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Wednesday

Thursday

Friday

Wednesday, 9 September

11:00 – 12:00	Registration/light lunch
OSZ 1	Opening
12:00 - 12:10	Welcome to the Goethe University, Otto Stern Center Enrico Schleiff, Vice President, Goethe University
12:10 - 12:20	Thomas Braun (Acting President, GSCN)
12:30 – 13:15	Keynote lecture I K1 - Epigenetic reactivation of adult epicardium underpins endogenous heart repair Paul Riley, University of Oxford, U.K. (Chair: Thomas Braun)
13:15 – 14:00	Keynote lecture II K2 - Modeling human lung development and disease using pluripotent stem cells Hans-Willem Snoeck, Columbia University, New York, U.S.A. (Chair: Ulrich Martin)
14:00 – 14:30	Coffee break/industry exhibition
Concurrent scientific working group session I
OSZ 3	Stem cells in regenerative therapies I (Chairs: Michael Cross/Ulrich Martin) Note: Session change - new presentation and speaker change
14:30 - 14:45	Overview Michael Cross, University of Leipzig
14:45 - 15:00	T01 - Pulmonary macrophage transplantation employing HSC- or iPSC-derived cells as an innovative gene therapy approach in Pulmonary Alveolar Proteinosis Nico Lachmann, Hannover Medical School
15:00 - 15:15	T02 - Cardiomyogenesis of human pluripotent stem cells is associated with transformation of metabolism and expression of specific PDLIM5 splice variants Sarah A. Konze, Hannover Medical School
15:15 - 15:30	T03 - Gene modification in stem cells targeting megakaryopoiesis Lisette Johanna Latorre Rey, Paul Ehrlich Institute, Langen
15:30 - 15:45	T04 - A novel cell surface marker for the enrichment of transplantable dopaminergic precursor cells from differentiated human pluripotent stem cells Andreas Bosio, Miltenyi Biotec GmbH, Bergisch Gladbach
15:45 - 16:00	Working group discussion “Stem cells in regenerative therapies”
OSZ 4	Pluripotency and embryonic stem cells (Chairs: Hans Schöler/Mathias Treier)
14:30 - 14:45	Overview Hans Schöler, Max Planck Institute for Molecular Biomedicine, Münster
14:45 - 15:00	T05 - Foxd3 promotes the exit from naïve pluripotency and prevents germline specification through enhancer decommissioning Alvaro Rada-Iglesias, CMMC, University of Cologne
15:00 - 15:15	T06 - Ground state conditions induce rapid reorganization of core pluripotency factor binding before global epigenetic reprogramming Christina Galonska, Havard University, Cambridge, U.S.A.
15:15 - 15:30	T07 - TDP-43 safeguards pluripotency by regulation of alternative polyadenylation Miha Modic, Helmholtz Center Munich and MRC LMB Cambridge, U.K.
15:30 - 15:45	T08 - LncRNA Panct1 maintains mouse embryonic stem cell identity by recruiting TOBF1 to OCT-SOX sequences in early G1 Debojyoti Chakraborty, Dresden University of Technology
15:45 - 16:00	T09 - Decoding the heterogeneity of pluripotent stem cells at the single cell level Simon Hastreiter, ETH Zürich BSSE, Basel, Switzerland
OSZ 6	Computational stem cell biology (Chairs: Georg Fuellen/Ingo Röder)
14:30 - 14:45	Overview Georg Fuellen, IBIMA, University of Rostock
14:45 - 15:00	T10 - Morpheus: computational modeling for stem cell biologists Walter de Back, Dresden University of Technology
15:00 - 15:15	T11 - Inference of spatiotemporal effects on cellular state transitions from time-lapse microscopy Michael Strasser, Helmholtz Center Munich
15:15 - 15:30	T12 - Prospective identification of hematopoietic lineage choice Carsten Marr, Helmholtz Center Munich
15:30 - 15:45	T13 - On the quantification of hematopoietic tissue remodeling in aging and disease: simulations, measures and predictions Christoph Baldow, Dresden University of Technology
15:45 - 16:00	Working group discussion “Computational stem cell biology”
16:00 – 16:30	Coffee break/industry exhibition
16:30 – 18:30	Poster session I: P001 - P074 P001 - P024: Hematopoietic stem cells P025 - P038: Stem cells in regenerative therapies P039 - P048: Stem cells in regenerative therapies: Mesenchymal stem/stroma cells P049 - P074: Stem cells in disease modeling and drug development Even numbers: please present your poster from 16:30 - 17:30 Odd numbers: 17:30 - 18:30
18:30 – 21:00	Informal GSCN Get together for all participants with dinner buffet at the foyer of the Otto Stern Center

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Thursday, 10 September

Concurrent scientific working group session II
OSZ 3	Stem cells in disease modeling and drug development (Chairs: Karl-Ludwig Laugwitz/Oliver Brüstle)
09:00 - 09:15	Overview Karl-Ludwig Laugwitz, Technische Universität München
09:15 - 09:30	T14 - Infection, innate immune signaling and cancer in the stomach – stem cell-derived organoids as a new model Sina Bartfeld, Hubrecht Institute, Utrecht, Netherlands
09:30 - 09:45	T15 - Modeling reactive gliosis in mESC-derived retina organoids Manuela Völkner, DZNE Dresden
09:45 - 10:00	T16 - Patient iPSC-derived NPCs as a model for mtDNA mutations reveal HCS/HTS-suitable phenotypes Raul Bukowiecki, Max Delbrück Center, Berlin
10:00 - 10:15	T17 - Intracellular calcium-release and autophagy modulation trigger ataxin-3 positive nuclear inclusions in Machado-Joseph disease-specific neurons Johannes Jungverdorben, Institute of Reconstructive Neurobiology, Bonn
10:15 - 10:30	Working group discussion “Stem cells in disease modeling and drug development”
OSZ 4	Stem cells in disease: cancer stem cells (Chairs: Thomas Brabletz/Andreas Trumpp)
09:00 - 09:15	Overview Thomas Brabletz, FAU Erlangen
09:15 - 09:30	T18 - Epigenetic age-predictions in cancer: aging signatures are associated with malignant transformation and clinical prognosis Wolfgang Wagner, RWTH Aachen Medical School
09:30 - 09:45	T19 - Triple-negative inflammatory breast cancer: syndecan-1 is a biomarker and regulator of cancer stem cell phenotype via IL-6/STAT-3 and Notch-3 Sherif A. Ibrahim, Faculty of Science, Cairo University, Egypt
09:45 - 10:00	T20 - Targeting tumor-initiating stem cells in colorectal carcinoma Ilaria Lunger, Goethe University Hospital and LOEWE Center Frankfurt
10:00 - 10:15	T21 - Unraveling the subclonal architecture of adult B-ALL at a single cell level Bartosch Wojcik, Goethe University Hospital and LOEWE Center Frankfurt
10:15 - 10:30	Working group discussion “Stem cells in disease: cancer stem cells”
OSZ 6	Stem cells in development (Chairs: Jan Lohmann/Thomas Braun)
09:00 - 09:15	Overview Jan Lohmann, Centre for Organismal Studies (COS) Heidelberg
09:15 - 09:30	T22 - Understanding the curious case of trophoblast differentiation Micha Drukker, Helmholtz Center Munich
09:30 - 09:45	T23 - The Ca²⁺-regulated phosphatase calcineurin controls proportional growth of zebrafish regenerating fins Christopher Antos, DFG-Center for Regenerative Therapies/ TU Dresden
09:45 - 10:00	T24 - Antagonistic roles of miR-181a and orphan nuclear receptor GCNF in regulating human neural stem cell maintenance Laura Stappert, Institute of Reconstructive Neurobiology, Bonn
10:00 - 10:15	T25 - Direct Nkx2-5 transcriptional repression of Isl1 controls cardiomyocyte subtype identity Jessica Haas, Klinikum r.d.I. der TUM, Muinch
10:15 - 10:30	T26 - Hypoxia induced epigenetic mechanism underlying Isl1+ cardiac progenitor cell homeostasis control Xuejun Yuan, Max Planck Institute for Heart and Lung Research, Bad Nauheim
10:30 – 11:00	Coffee break/industry exhibition
Industry session: "Technologies from GSCN industry partners"
OSZ 3	Main supporters (Chair: Albrecht Müller)
11:00 - 11:05	Introduction
11:05 - 11:35	C1 – Robust expansion of human pluripotent stem cells: integration of bioprocess design with transcriptomic and metabolomic characterization Margarida Serra, Instituto de Tecnologia Química e Biológica (ITQB), Universidade Nova de Lisboa (UNL), Oeiras, Portugal, representing Eppendorf AG
11:35 - 12:05	C2 – A human iPS cell platform to study pancreatic disease Alexander Kleger, University Hospital Ulm, representing PeproTech GmbH
12:05 - 12:35	C3 – Advances in pluripotent stem cell culture and differentiation David Kuninger, Thermo Fisher Scientific/Life Technologies GmbH
OSZ 4	Supporters (Chair: Hartmut Geiger)
11:00 - 11:05	Introduction
11:05 - 11:35	C4 – Consistency of pluripotent stem cell culture systems and differentiation protocols for generation of functional human stem cell derived hepatocytes Mia Emgård, Takara Clontech
11:35 - 12:05	C5 – Reprogramming of somatic cells to induced pluripotent stem cells using a novel synthetic self-replicating RNA vector in a feeder-free system Alexandra Blak, STEMCELL Technologies SARL
12:05 - 12:35	C6 – High throughput electrospinning to generate scaffolds containing cells for regenerative medicine applications Thomas Hayes, BioInicia S.L./I&L Biosystems GmbH
OSZ 6	Supporters (Chair: Ana Martin-Villalba)
11:00 - 11:05	Introduction
11:05 - 11:35	C7 – An optimal serum-free, xeno-free culture system for the isolation, expansion and differentiation of clinical grade human mesenchymal stem cells Orit Ecker-Cohen, Biological Industries/Biofroxx GmbH
11:35 - 12:05	C8 – Explore what makes every stem cell unique from the inside out Mark Lynch, Fluidigm Europe B.V.
12:05 - 12:35	C9 – GrowDex® hydrogel for 3D cell cultures Lauri Paasonen, UPM-Kymmene Corporation
12:35 - 14:00	Lunch buffet/industry exhibition/poster viewing
12:50 - 13:45	Showcase: Outreach + Patient Information (Chairs: Ira Herrmann/Tobias Cantz)
OSZ 1	Presidential Symposium (Chair: Thomas Braun)
14:00 – 14:30	PS1 – Evolving stem cell-based strategies for targeting neurological disorders Oliver Brüstle, Institute of Reconstructive Neurobiology, Bonn
14:30 – 15:00	Young Investigator Award PS2 – In vitro cell culture models to decipher brain development and neuronal integration Julia Ladewig, Institute of Reconstructive Neurobiology, Bonn
15:00 – 15:30	Female Scientist Award PS3 – From neurogenesis to neural repair Magdalena Götz, Helmholtz Center Munich
15:30 – 16:00	Publication of the Year 2015 Award (June 2014 - 2015) PS4 – Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells Jichang Wang (w. Zsuzsanna Izsvak), Max Delbrück Center, Berlin
16:00 – 16:30	Coffee break/industry exhibition
16:30 – 18:30	Poster session II: P075 - P147 P075 - P093: Pluripotency and embryonic stem cells P094 - P107: Programing and Reprograming P108 - P113: Somatic stem cells P114 - P130: Stem cells in development P131 - P143: Stem cells in disease: Cancer stem cells P144 - P147: Computational stem cell biology Even numbers: please present your poster from 16:30 - 17:30 Odd numbers: 17:30 - 18:30
18:30 – 19:30	Membership meeting
19:30 - 20:00	Bus transfer
20:00 – 01:00	GSCN Networking evening for all participants with dinner buffet and DJ at the Banquet Hall I, Casino, Campus Westend

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Friday, 11 September

Concurrent scientific working group session III
OSZ 3	Hematopoietic stem cells (Chairs: Timm Schroeder/Claudia Waskow)
09:00 - 09:15	Overview Timm Schroeder, ETH Zürich BSSE, Basel, Switzerland
09:15 - 09:30	T27 - CCND1/CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem and progenitor cells in vivo Nicole Mende, Dresden University of Technology
09:30 - 09:45	T28 - The H3K4 histone methyltransferase Setd1b is required for haematopoietic stem cell homeostasis in mice Kerstin Schmidt, Biotechnology Center TU Dresden
09:45 - 10:00	T29 - Molecular and functional heterogeneity of dormant HSCs Nina Cabezas-Wallscheid, German Cancer Research Center (DKFZ) Heidelberg
10:00 - 10:15	T30 - High efficiency gene correction in hematopoietic cells by template-free CRISPR/Cas9 genome editing Frank Schnütgen, University Hospital Frankfurt
10:15 - 10:30	Working group discussion “Basic, translational and applied hematopoiesis”
OSZ 4	Somatic stem cells (Chairs: Ana Martin-Villalba/Michael Rieger)
09:00 - 09:15	Overview Ana Martin-Villalba, German Cancer Research Center (DKFZ) Heidelberg
09:15 - 09:30	T31 - Visualization of the short-range Wnt gradient in the intestinal stem cell niche Henner Farin, Georg-Speyer-Haus, Frankfurt
09:30 - 09:45	T32 - Clonal heterogeneity within the exocrine pancreas Damian Wollny, German Cancer Research Center (DKFZ) Heidelberg
09:45 - 10:00	T33 - Single cell analysis of cellular mechanisms regulating adult neural stem cell fate Onur Basak, Hubrecht Institute, Utrecht, Netherlands
10:00 - 10:15	T34 - In vivo Ribotag analysis reveals translational control during neural stem cell differentiation Avni Baser, German Cancer Research Center (DKFZ) Heidelberg
10:15 - 10:30	Working group discussion “Somatic stem cells and development”
OSZ 5	Stem cells in reg. therapies II: Mesenchymal stem/stroma cells (Chairs: Dirk Strunk/Karen Bieback)
09:00 - 09:15	Overview Dirk Strunk, Paracelsus Medical University, Salzburg, Austria
09:15 - 09:30	T35 - The transcription factor GATA2 controls mesenchymal stem cell fate Alexander Tolkachov, Center for Cardiovascular Research, Charité, Berlin
09:30 - 09:45	T36 - Attenuation of alloimmunity to human endothelial colony forming cells (ECFC) by interaction with mesenchymal stem/progenitor cells (MSPC) Naima Souidi, Berlin-Brandenburg Center for Regenerative Medicine and Institute of Medical Immunology, Charité, Berlin
09:45 - 10:00	T37 - Murine bone marrow derived mesenchymal stem cells as a putative therapy approach for influenza-virus induced pneumonia Lina Jankauskaite, Universities of Giessen and Marburg Lung Center (UGMLC), Giessen
10:00 - 10:15	T38 - Regenerative potential of human pluripotent stem cell-derived MSCs in a Gunn rat liver injury model Lucas-Sebastian Spitzhorn, University Hospital of Düsseldorf
	Working group discussion “Stem cells in regenerative therapies” - future progress with MSCs
OSZ 6	Programing and reprograming (Chairs: Micha Drukker/Frank Edenhofer)
09:00 - 09:15	Overview Micha Drukker, Helmholtz Center Munich
09:15 - 09:30	T39 - An inducible overexpression system for rapid and highly efficient induction of mature cell types from human pluripotent stem cells Matthias Pawlowski, Cambridge Stem Cell Institute, U.K.
09:30 - 09:45	T40 - Reprogramming triggers endogenous LINE-1, Alu and SVA retrotransposition in human induced pluripotent stem cells affecting host gene expression Gerald Schumann, Paul Ehrlich Institute, Langen
09:45 - 10:00	T41 – Efficient patterning of human pluripotent stem cells towards distinct mesendodermal subtypes simply by modulation of the bulk cell density Henning Kempf, Hannover Medical School
10:00 - 10:15	T42 - Direct in vivo glia-to-neuron conversion in the postnatal mouse cerebral cortex Sophie Péron, Institute of Physiological Chemistry, Johannes Gutenberg University Mainz
10:15 - 10:30	Working group discussion “Pluripotency and reprograming”
10:30 - 11:00	Coffee break/industry exhibition
Concurrent strategic working group session
OSZ 3	Stem cell technologies (Chairs: Frank Emmrich/Andreas Bosio)
11:00 - 11:30	S1 - Technologies in genetic engineering of stem cells Ulrich Martin, Hannover Medical School
11:30 - 12:00	S2 - Genetic engineering of human pluripotent stem cells using TALENs nucleases Sebastian Diecke, Max Delbrück Center, Berlin
12:00 - 12:30	S3 - Mammalian genome engineering in the era of CRISPR/Cas Ralf Kühn, Max Delbrück Center, Berlin
OSZ 4	Career development (Chairs: Insa Schröder/Hartmut Geiger)
11:00 - 11:15	Introduction Insa Schröder, GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt
11:15 - 12:00	S4 - How to apply in research and industry Hanna Proner, academics/Die Zeit, Hamburg
12:00 - 12:30	Panel discussion
OSZ 5	Clinical trials and regulatory affairs (Chairs: Andreas Kurtz/Halvard Bönig)
11:00 - 11:05	Introduction Andreas Kurtz, Berlin-Brandenburg Center for Regenerative Medicine, Charité, Berlin
11:05 - 11:25	S5 - Regulatory aspects and classifications of stem cell based medicinal products Egbert Flory, Paul Ehrlich Institute, Langen
11:25 - 11:45	S6 - Accelerating the clinical development of cell based therapies Natalie Mount, Cell Therapy Catapult, London, U.K.
11:45 - 12:00	S7 - The ADIPOA-1/-2 trial - Adipose tissue derived stromal cells for osteoarthritis therapy Oliver Pullig, Fraunhofer IGB, Würzburg branch
12:00 - 12:15	S8 - Cell Therapy for bone defects: in vitro, in vivo, and first clinical results Ingo Marzi, Goethe University Hospital, Frankfurt
12:15 - 12:30	Panel discussion
12:30 – 14:00	Lunch buffet/industry exhibition/poster viewing
12:45 - 13:45	Meet-the-expert table: Stem cell technologies – CRISPR/Cas Technology (Ralf Kühn) and – TALENs Technology (Sebastian Diecke) limited to 10 registered participants each
12:45 - 13:45	Drop-in booth on regulatory affairs and clinical trials with Egbert Flory, Natalie Mount, u.a.
OSZ 1	Joined session with LOEWE Center for Cell and Gene Theraty Frankfurt (CGT)
14:00 - 14:45	Keynote lecture III K3 - Pluripotency in the artificial cell space Andras Nagy, Lunenfeld-Tanenbaum Research Institute, Toronto, Canada (Chair: Harald von Melchner)
14:45 - 15:30	Keynote lecture IV K4 - Modeling and treating neural disease using human pluripotent stem cells Lorenz Studer, Memorial Sloan Kettering Cancer Center, New York (Chair: Lenhard Rudolph)
15:30 - 16:00	Coffee break/industry exhibition
OSZ 1	CGT Session (Chair: Lenhard Rudolph)
16:00 - 16:20	CGT1 - Regulation of second heart field progenitor cells: discovering key molecular players Gergana Dobreva, Max Planck Institute for Heart and Lung Research, Bad Nauheim
16:20 - 16:40	CGT2 - Functional systems analysis of the adult muscle stem cell identifies crucial regulators of muscle regeneration Johnny Kim, Max Planck Institute for Heart and Lung Research, Bad Nauheim
16:40 - 17:00	CGT3 - Hematopoietic stem cell fate decision control at single cell resolution Michael Rieger, Goethe University Hospital and LOEWE Center Frankfurt
17:00 - 17:20	CGT4 - The Sleeping Beauty transposon system for genetic engineering in stem cells Zoltán Ivics, Paul Ehrlich Institute, Langen
OSZ 1	Closing ceremony
17:30 - 17:45	Poster award ceremony and announcement of industry quiz winners (Daniel Besser; GSCN) supported by PeproTech GmbH
17:45 - 18:00	Outlook and closing remarks Incoming president: Ulrich Martin
End of GSCN conference 2015

Announcement:
19:00 – 20:00	GSCN Public outreach event at the Hall West, Campus Westend
20:00 – 21:00	Reception public outreach event

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Program

Wednesday, 9 September

Thursday, 10 September

Friday, 11 September

Supporters