download the short program here
and the complete program (including abstracts)   here

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Wednesday Thursday  Friday

Wednesday, 9 September

11:00 – 12:00  Registration/light lunch
12:00 - 12:10 Welcome to the Goethe University, Otto Stern Center
Enrico Schleiff, Vice President, Goethe University
12:10 - 12:20 Thomas Braun (Acting President, GSCN)
12:30 – 13:15 
Keynote lecture I
K1 - Epigenetic reactivation of adult epicardium underpins endogenous heart repair
Paul Riley, University of Oxford, U.K. (Chair: Thomas Braun)
13:15 – 14:00 Keynote lecture II
K2 - Modeling human lung development and disease using pluripotent stem cells
Hans-Willem Snoeck, Columbia University, New York, U.S.A. (Chair: Ulrich Martin)
14:00 – 14:30
Coffee break/industry exhibition
Concurrent scientific working group session I
Stem cells in regenerative therapies I  (Chairs: Michael Cross/Ulrich Martin)
Note: Session change - new presentation and speaker change
14:30 - 14:45 Overview
Michael Cross, University of Leipzig
14:45 - 15:00 T01 - Pulmonary macrophage transplantation employing HSC- or iPSC-derived cells as an innovative gene therapy approach in Pulmonary Alveolar Proteinosis
Nico Lachmann, Hannover Medical School
15:00 - 15:15 T02 - Cardiomyogenesis of human pluripotent stem cells is associated with transformation of metabolism and expression of specific PDLIM5 splice variants
Sarah A. Konze, Hannover Medical School
15:15 - 15:30 T03 - Gene modification in stem cells targeting megakaryopoiesis
Lisette Johanna Latorre Rey, Paul Ehrlich Institute, Langen
15:30 - 15:45 T04 - A novel cell surface marker for the enrichment of transplantable dopaminergic precursor cells from differentiated human pluripotent stem cells
Andreas Bosio, Miltenyi Biotec GmbH, Bergisch Gladbach

15:45 - 16:00 Working group discussion “Stem cells in regenerative therapies”
OSZ 4 Pluripotency and embryonic stem cells  (Chairs: Hans Schöler/Mathias Treier)
14:30 - 14:45 Overview
Hans Schöler, Max Planck Institute for Molecular Biomedicine, Münster
14:45 - 15:00 T05 - Foxd3 promotes the exit from naïve pluripotency and prevents germline specification through enhancer decommissioning
Alvaro Rada-Iglesias, CMMC, University of Cologne
15:00 - 15:15 T06 - Ground state conditions induce rapid reorganization of core pluripotency factor binding before global epigenetic reprogramming
Christina Galonska, Havard University, Cambridge, U.S.A.
15:15 - 15:30 T07 - TDP-43 safeguards pluripotency by regulation of alternative polyadenylation
Miha Modic, Helmholtz Center Munich and MRC LMB Cambridge, U.K.
15:30 - 15:45 T08 - LncRNA Panct1 maintains mouse embryonic stem cell identity by recruiting TOBF1 to OCT-SOX sequences in early G1
Debojyoti Chakraborty, Dresden University of Technology
15:45 - 16:00 T09 - Decoding the heterogeneity of pluripotent stem cells at the single cell level
Simon Hastreiter, ETH Zürich BSSE, Basel, Switzerland
OSZ 6 Computational stem cell biology  (Chairs: Georg Fuellen/Ingo Röder)
14:30 - 14:45 Overview
Georg Fuellen, IBIMA, University of Rostock
14:45 - 15:00 T10 - Morpheus: computational modeling for stem cell biologists
Walter de Back, Dresden University of Technology
15:00 - 15:15 T11 - Inference of spatiotemporal effects on cellular state transitions from time-lapse microscopy
Michael Strasser, Helmholtz Center Munich
15:15 - 15:30 T12 - Prospective identification of hematopoietic lineage choice
Carsten Marr, Helmholtz Center Munich
15:30 - 15:45 T13 - On the quantification of hematopoietic tissue remodeling in aging and disease: simulations, measures and predictions
Christoph Baldow, Dresden University of Technology
15:45 - 16:00 Working group discussion “Computational stem cell biology”
16:00 – 16:30 Coffee break/industry exhibition
16:30 – 18:30 Poster session I: P001 - P074
P001 - P024: Hematopoietic stem cells
P025 - P038: Stem cells in regenerative therapies
P039 - P048: Stem cells in regenerative therapies:
                      Mesenchymal stem/stroma cells
P049 - P074: Stem cells in disease 
modeling and drug development

Even numbers: please present your poster from 16:30 - 17:30
Odd numbers: 17:30 - 18:30
18:30 – 21:00 Informal GSCN Get together for all participants
with dinner buffet at the foyer of the Otto Stern Center


Thursday, 10 September

Concurrent scientific working group session II

OSZ 3 Stem cells in disease modeling and drug development  (Chairs: Karl-Ludwig Laugwitz/Oliver Brüstle)  
09:00 - 09:15 Overview
Karl-Ludwig Laugwitz, Technische Universität München
09:15 - 09:30 T14 - Infection, innate immune signaling and cancer in the stomach – stem cell-derived organoids as a new model
Sina Bartfeld, Hubrecht Institute, Utrecht, Netherlands
09:30 - 09:45 T15 - Modeling reactive gliosis in mESC-derived retina organoids
Manuela Völkner, DZNE Dresden
09:45 - 10:00 T16 - Patient iPSC-derived NPCs as a model for mtDNA mutations reveal HCS/HTS-suitable phenotypes
Raul Bukowiecki, Max Delbrück Center, Berlin
10:00 - 10:15 T17 - Intracellular calcium-release and autophagy modulation trigger ataxin-3 positive nuclear inclusions in Machado-Joseph disease-specific neurons
Johannes Jungverdorben, Institute of Reconstructive Neurobiology, Bonn
10:15 - 10:30 Working group discussion “Stem cells in disease modeling and drug development”
Stem cells in disease: cancer stem cells (Chairs: Thomas Brabletz/Andreas Trumpp)
09:00 - 09:15 Overview
Thomas Brabletz, FAU Erlangen
09:15 - 09:30 T18 - Epigenetic age-predictions in cancer: aging signatures are associated with malignant transformation and clinical prognosis
Wolfgang Wagner, RWTH Aachen Medical School
09:30 - 09:45 T19 - Triple-negative inflammatory breast cancer: syndecan-1 is a biomarker and regulator of cancer stem cell phenotype via IL-6/STAT-3 and Notch-3
Sherif A. Ibrahim, Faculty of Science, Cairo University, Egypt
09:45 - 10:00 T20 - Targeting tumor-initiating stem cells in colorectal carcinoma
Ilaria Lunger, Goethe University Hospital and LOEWE Center Frankfurt
10:00 - 10:15 T21 - Unraveling the subclonal architecture of adult B-ALL at a single cell level
Bartosch Wojcik, Goethe University Hospital and LOEWE Center Frankfurt
10:15 - 10:30 Working group discussion “Stem cells in disease: cancer stem cells”
Stem cells in development (Chairs: Jan Lohmann/Thomas Braun)  
09:00 - 09:15 Overview
Jan Lohmann, Centre for Organismal Studies (COS) Heidelberg
09:15 - 09:30 T22 - Understanding the curious case of trophoblast differentiation
Micha Drukker, Helmholtz Center Munich
09:30 - 09:45 T23 - The Ca2+-regulated phosphatase calcineurin controls proportional growth of zebrafish regenerating fins
Christopher Antos, DFG-Center for Regenerative Therapies/ TU Dresden
09:45 - 10:00 T24 - Antagonistic roles of miR-181a and orphan nuclear receptor GCNF in regulating human neural stem cell maintenance
Laura Stappert, Institute of Reconstructive Neurobiology, Bonn
10:00 - 10:15 T25 - Direct Nkx2-5 transcriptional repression of Isl1 controls cardiomyocyte subtype identity
Jessica Haas, Klinikum r.d.I. der TUM, Muinch
10:15 - 10:30 T26 - Hypoxia induced epigenetic mechanism underlying Isl1+ cardiac progenitor cell homeostasis control
Xuejun Yuan, Max Planck Institute for Heart and Lung Research, Bad Nauheim
10:30 – 11:00
Coffee break/industry exhibition

Industry session: "Technologies from GSCN industry partners"
Main supporters (Chair: Albrecht Müller)
11:00 - 11:05 Introduction  
11:05 - 11:35 C1 – Robust expansion of human pluripotent stem cells: integration of bioprocess design with transcriptomic and metabolomic characterization
Margarida Serra, Instituto de Tecnologia Química e Biológica (ITQB), Universidade Nova de Lisboa (UNL), Oeiras, Portugal, representing Eppendorf AG
11:35 - 12:05 C2 – A human iPS cell platform to study pancreatic disease
Alexander Kleger, University Hospital Ulm, representing PeproTech GmbH
12:05 - 12:35 C3 – Advances in pluripotent stem cell culture and differentiation
David Kuninger, Thermo Fisher Scientific/Life Technologies GmbH
Supporters (Chair: Hartmut Geiger)

11:00 - 11:05 Introduction  
11:05 - 11:35 C4 – Consistency of pluripotent stem cell culture systems and differentiation protocols for generation of functional human stem cell derived hepatocytes
Mia EmgårdTakara Clontech
11:35 - 12:05 C5 – Reprogramming of somatic cells to induced pluripotent stem cells using a novel synthetic self-replicating RNA vector in a feeder-free system
Alexandra Blak, STEMCELL Technologies SARL 
12:05 - 12:35 C6 – High throughput electrospinning to generate scaffolds containing cells for regenerative medicine applications
Thomas Hayes, BioInicia S.L./I&L Biosystems GmbH
Supporters (Chair: Ana Martin-Villalba)
11:00 - 11:05 Introduction  
11:05 - 11:35 C7 – An optimal serum-free, xeno-free culture system for the isolation, expansion and differentiation of clinical grade human mesenchymal stem cells
Orit Ecker-Cohen, Biological Industries/Biofroxx GmbH
11:35 - 12:05 C8 – Explore what makes every stem cell unique from the inside out
Mark LynchFluidigm Europe B.V.
12:05 - 12:35 C9 – GrowDex® hydrogel for 3D cell cultures
Lauri Paasonen, UPM-Kymmene Corporation
12:35 - 14:00
Lunch buffet/industry exhibition/poster viewing

12:50 - 13:45 Showcase: Outreach + Patient Information (Chairs: Ira Herrmann/Tobias Cantz)  
Presidential Symposium (Chair: Thomas Braun)  
14:00 – 14:30
PS1 – Evolving stem cell-based strategies for targeting neurological disorders
Oliver Brüstle, Institute of Reconstructive Neurobiology, Bonn

14:30 – 15:00  Young Investigator Award
PS2 – In vitro cell culture models to decipher brain development and neuronal integration
Julia Ladewig, Institute of Reconstructive Neurobiology, Bonn

15:00 – 15:30
Female Scientist Award
PS3 – From neurogenesis to neural repair
Magdalena Götz, Helmholtz Center Munich

15:30 – 16:00  Publication of the Year 2015 Award (June 2014 - 2015)
PS4 – Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells 
Jichang Wang (w. Zsuzsanna Izsvak), Max Delbrück Center, Berlin

16:00 – 16:30
Coffee break/industry exhibition

16:30 – 18:30 Poster session II: P075 - P147
P075 - P093: Pluripotency and embryonic stem cells
P094 - P107: Programing and Reprograming
P108 - P113: Somatic stem cells
P114 - P130: Stem cells in development
P131 - P143: Stem cells in disease: Cancer stem cells 
P144 - P147: Computational stem cell biology

Even numbers: please present your poster from 16:30 - 17:30
Odd numbers: 17:30 - 18:30

18:30 – 19:30 Membership meeting

19:30 - 20:00 Bus transfer  
20:00 – 01:00
GSCN Networking evening for all participants
with dinner buffet and DJ at the Banquet Hall I, Casino, Campus Westend


Friday, 11 September

Concurrent scientific working group session III 
OSZ 3 Hematopoietic stem cells  (Chairs: Timm Schroeder/Claudia Waskow)
09:00 - 09:15 Overview
Timm Schroeder, ETH Zürich BSSE, Basel, Switzerland
09:15 - 09:30 T27 - CCND1/CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem and progenitor cells in vivo
Nicole Mende, Dresden University of Technology
09:30 - 09:45 T28 - The H3K4 histone methyltransferase Setd1b is required for haematopoietic stem cell homeostasis in mice
Kerstin Schmidt, Biotechnology Center TU Dresden
09:45 - 10:00 T29 - Molecular and functional heterogeneity of dormant HSCs
Nina Cabezas-Wallscheid, German Cancer Research Center (DKFZ) Heidelberg
10:00 - 10:15 T30 - High efficiency gene correction in hematopoietic cells by template-free CRISPR/Cas9 genome editing
Frank Schnütgen, University Hospital Frankfurt
10:15 - 10:30 Working group discussion “Basic, translational and applied hematopoiesis”
OSZ 4 Somatic stem cells (Chairs: Ana Martin-Villalba/Michael Rieger)
09:00 - 09:15 Overview
Ana Martin-Villalba, German Cancer Research Center (DKFZ) Heidelberg
09:15 - 09:30 T31 - Visualization of the short-range Wnt gradient in the intestinal stem cell niche
Henner Farin, Georg-Speyer-Haus, Frankfurt
09:30 - 09:45 T32 - Clonal heterogeneity within the exocrine pancreas
Damian Wollny, German Cancer Research Center (DKFZ) Heidelberg
09:45 - 10:00 T33 - Single cell analysis of cellular mechanisms regulating adult neural stem cell fate
Onur Basak, Hubrecht Institute, Utrecht, Netherlands
10:00 - 10:15 T34 - In vivo Ribotag analysis reveals translational control during neural stem cell differentiation
Avni Baser, German Cancer Research Center (DKFZ) Heidelberg
10:15 - 10:30 Working group discussion “Somatic stem cells and development”
Stem cells in reg. therapies II: Mesenchymal stem/stroma cells (Chairs: Dirk Strunk/Karen Bieback)
09:00 - 09:15 Overview
Dirk Strunk, Paracelsus Medical University, Salzburg, Austria
09:15 - 09:30 T35 - The transcription factor GATA2 controls mesenchymal stem cell fate
Alexander Tolkachov, Center for Cardiovascular Research, Charité, Berlin
09:30 - 09:45 T36 - Attenuation of alloimmunity to human endothelial colony forming cells (ECFC) by interaction with mesenchymal stem/progenitor cells (MSPC)
Naima Souidi, Berlin-Brandenburg Center for Regenerative Medicine and Institute of Medical Immunology, Charité, Berlin
09:45 - 10:00 T37 - Murine bone marrow derived mesenchymal stem cells as a putative therapy approach for influenza-virus induced pneumonia
Lina Jankauskaite, Universities of Giessen and Marburg Lung Center (UGMLC), Giessen
10:00 - 10:15 T38 - Regenerative potential of human pluripotent stem cell-derived MSCs in a Gunn rat liver injury model
Lucas-Sebastian Spitzhorn, University Hospital of Düsseldorf

Working group discussion “Stem cells in regenerative therapies” - future progress with MSCs
OSZ 6 Programing and reprograming (Chairs: Micha Drukker/Frank Edenhofer)
09:00 - 09:15 Overview
Micha Drukker, Helmholtz Center Munich
09:15 - 09:30 T39 - An inducible overexpression system for rapid and highly efficient induction of mature cell types from human pluripotent stem cells
Matthias Pawlowski, Cambridge Stem Cell Institute, U.K.
09:30 - 09:45 T40 - Reprogramming triggers endogenous LINE-1, Alu and SVA retrotransposition in human induced pluripotent stem cells affecting host gene expression
Gerald Schumann, Paul Ehrlich Institute, Langen
09:45 - 10:00 T41 – Efficient patterning of human pluripotent stem cells towards distinct mesendodermal subtypes simply by modulation of the bulk cell density
Henning Kempf, Hannover Medical School
10:00 - 10:15 T42 - Direct in vivo glia-to-neuron conversion in the postnatal mouse cerebral cortex
Sophie Péron, Institute of Physiological Chemistry, Johannes Gutenberg University Mainz
10:15 - 10:30 Working group discussion “Pluripotency and reprograming”
10:30 - 11:00
Coffee break/industry exhibition
Concurrent strategic working group session
OSZ 3 Stem cell technologies (Chairs: Frank Emmrich/Andreas Bosio)
11:00 - 11:30 S1 - Technologies in genetic engineering of stem cells
Ulrich Martin, Hannover Medical School
11:30 - 12:00 S2 - Genetic engineering of human pluripotent stem cells using TALENs nucleases
Sebastian Diecke, Max Delbrück Center, Berlin
12:00 - 12:30 S3 - Mammalian genome engineering in the era of CRISPR/Cas
Ralf Kühn, Max Delbrück Center, Berlin
OSZ 4 Career development (Chairs: Insa Schröder/Hartmut Geiger)
11:00 - 11:15 Introduction
Insa Schröder, GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt
11:15 - 12:00 S4 - How to apply in research and industry
Hanna Proner, academics/Die Zeit, Hamburg
12:00 - 12:30 Panel discussion
Clinical trials and regulatory affairs (Chairs: Andreas Kurtz/Halvard Bönig)
11:00 - 11:05 Introduction
Andreas Kurtz, Berlin-Brandenburg Center for Regenerative Medicine, Charité, Berlin
11:05 - 11:25 S5 - Regulatory aspects and classifications of stem cell based medicinal products
Egbert Flory, Paul Ehrlich Institute, Langen
11:25 - 11:45 S6 - Accelerating the clinical development of cell based therapies
Natalie Mount, Cell Therapy Catapult, London, U.K.
11:45 - 12:00 S7 - The ADIPOA-1/-2 trial - Adipose tissue derived stromal cells for osteoarthritis therapy
Oliver Pullig, Fraunhofer IGB, Würzburg branch
12:00 - 12:15 S8 - Cell Therapy for bone defects: in vitro, in vivo, and first clinical results
Ingo Marzi, Goethe University Hospital, Frankfurt 
12:15 - 12:30 Panel discussion
12:30 – 14:00
Lunch buffet/industry exhibition/poster viewing
12:45 - 13:45 Meet-the-expert table: Stem cell technologies – CRISPR/Cas Technology (Ralf Kühn) and – TALENs Technology (Sebastian Diecke) limited to 10 registered participants each
 12:45 - 13:45 Drop-in booth on regulatory affairs and clinical trials with Egbert Flory, Natalie Mount, u.a.
OSZ 1 Joined session with LOEWE Center for Cell and Gene Theraty Frankfurt (CGT)
14:00 - 14:45
Keynote lecture III
K3 - Pluripotency in the artificial cell space
Andras Nagy, Lunenfeld-Tanenbaum Research Institute, Toronto, Canada (Chair: Harald von Melchner)
14:45 - 15:30
Keynote lecture IV
K4 - Modeling and treating neural disease using human pluripotent stem cells
Lorenz Studer, Memorial Sloan Kettering Cancer Center, New York (Chair: Lenhard Rudolph)
15:30 - 16:00
Coffee break/industry exhibition
 OSZ 1 CGT Session (Chair: Lenhard Rudolph)
16:00 - 16:20 CGT1 - Regulation of second heart field progenitor cells: discovering key molecular players
Gergana Dobreva, Max Planck Institute for Heart and Lung Research, Bad Nauheim
16:20 - 16:40 CGT2 - Functional systems analysis of the adult muscle stem cell identifies crucial regulators of muscle regeneration
Johnny KimMax Planck Institute for Heart and Lung Research, Bad Nauheim

16:40 - 17:00 CGT3 - Hematopoietic stem cell fate decision control at single cell resolution
Michael Rieger, Goethe University Hospital and LOEWE Center Frankfurt
17:00 - 17:20 CGT4 - The Sleeping Beauty transposon system for genetic engineering in stem cells
Zoltán Ivics
,  Paul Ehrlich Institute, Langen
OSZ 1 Closing ceremony
17:30 - 17:45 Poster award ceremony and announcement of industry quiz winners
(Daniel Besser; GSCN)
supported by PeproTech GmbH 
17:45 - 18:00 Outlook and closing remarks
Incoming president: Ulrich Martin
End of GSCN conference 2015
19:00 – 20:00  GSCN Public outreach event at the Hall West, Campus Westend
20:00 – 21:00 Reception public outreach event