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Monday Tuesday  Wednesday

Monday, November 3rd

11:00 – 12:00  Registration and light lunch


12:00 - 12:05

Welcome to the German Cancer Research Center (DKFZ)
Ottmar Wiestler (Chairman and Scientific Director, DKFZ)
12:05 - 12:15 Andreas Trumpp (Acting President, GSCN)
12:15 - 12:30 Opening remarks
Bärbel Brumme-Bothe (Department Head "Life Sciences", BMBF)
12:30 – 13:15 
Keynote lecture I
Cancer Stem Cells
Eduard Batlle; Institute for Research in Biomedicine Barcelona, Spain
(chair: Andreas Trumpp)            supported by Eppendorf AG
13:15 – 14:00 Keynote lecture II
Myocardial regeneration by ESC-derived cardiac progenitors
Philippe Menasché
; University of Paris Descartes, Paris, France
(chair: Ulrich Martin)
14:00 – 14:30
Coffee break and industry exhibition
Concurrent scientific working group session I
Lecture hall:
Stem cells in regenerative therapies I (chair: Ulrich Martin/Hans-Dieter Volk)
14:30 – 14:50 Stem cells in regenerative therapies – Introduction
Ulrich Martin; Rebirth/Hannover Medical School
14:50 – 15:05 T01 – Intranasal delivery of migratory neural stem/progenitor cells: A non-invasive passage to therapeutically target intracerebral brain tumors
Nils Ole Schmidt; University Medical Center, Hamburg-Eppendorf 
15:05 – 15:20 T02 - MicroRNA-181a promotes human neuronal differentiation by down-regulating genes involved in neural stem cell maintenance
Laura Stappert; Institute of Reconstructive Neurobiology, Bonn
15:20 – 15:35 T03 - Pulmonary transplantation of multipotent- or pluripotent-stem cell derived macrophages as a novel treatment option for pulmonary alveolar proteinosis
Nico Lachmann; Hannover Medical School 
15:35 – 15:50 T04 - Human iPSC-derived MSC-like progenitor cells: functional differences from primary MSCs affecting their use in cartilage regenerative medicine
Solvig Diederichs; University Hospital Heidelberg
15:50 – 16:00 Group discussion
Room K1: Stem cells in disease: cancer stem cells (chair: Thomas Brabletz/ Andreas Trumpp) 
14:30 14:50 Concepts of cancer stem cells – Introduction
Andreas Trumpp; German Cancer Research Center, Heidelberg 
14:50 15:05 T05 - Shp2 Signaling is essential to the suppression of senescence in mammary gland cancer stem cells in mice
Linxiang Lan; Max Delbrück Center, Berlin
15:05 15:20 T06 - Humanization of mouse models for human breast cancer using mesenchymal stem cells
Maxine Silvestrov; Experimental Pharmacology & Oncology (EPO) GmbH, Berlin
15:20 15:35 T07 - Targeting the kinome to induce differentiation in human breast cancer stem cells
Jochen Maurer; University Medical Center Freiburg
15:35 15:50 T08 - CD151+ cells drive tumor-initiation, hierarchical growth and proliferation-associated signaling in patient-derived models of serous ovarian cancer
Franziska Zickgraf; German Cancer Research Center, Heidelberg 
15:50 16:00 Group discussion 
Room K 2: Computational stem cell biology (chair: Georg Fuellen/Ingo Roeder)
14:30 – 14:45 Computational stem cell biology – Overview and introduction
Ingo Roeder; Dresden University of Technology 
14:45 14:55 T09 - What makes stem cells move? Studying stem cell migration in vitro (back-to-back presentation with T10)
Michael Ansorge; Leipzig University 
14:44 15:05 T10 - What makes stem cells move? Studying stem cell migration in silico (back-to-back presentation with T09)
Axel Krinner; Dresden University of Technology
15:05 – 15:20 T11 - Characterizing transcriptional cell-to-cell heterogeneities during stem cell differentiation
Fabian Theis; Helmholtz Center Munich
15:20  15:35 T12 - A network-based strategy to direct cell fate determination
Antonio del Sol; Luxembourg Center for Systems Biomedicine 
15:35  15:50 T13 - Computational identification of pluripotency networks
Maryam Nazarieh; Saarland University, Saarbrücken 
15:50 16:00 Group discussion 
ZMBH (ground floor): Somatic stem cells (chair: Thomas Braun/Ana Martin-Villalba) 
14:30 14:50 Studies on somatic stem cells – An introduction
Thomas Braun; Max Planck Inst. f. Heart and Lung Res., Bad Nauheim 
14:40 15:05 T14 - The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs
Sarah Nicklas; Luxembourg Center for Systems Biomedicine 
15:05 15:20 T15 - Angiogenesis controls neural stem cell expansion by regulating tissue oxygenation and HIF signaling
Christian Lange; VIB KU Leuven Campus, Belgium 
15:20 15:35 T16 - Regulation of asymmetric/symmetric stem cell division in human epidermis
Katharina Nöske; German Cancer Research Center, Heidelberg 
15:35 15:50 T17 - Clonal heterogeneity within the exocrine pancreas
Damian Wollny; German Cancer Research Center, Heidelberg 
15:50  16:00 Group discussion 
16:00 – 16:15 Coffee break/industry exhibition
16:15 – 18:15 Poster session I: P001 – P097       supported by Fluidigm Europe B.V.
  (posters will be displayed in the tent)
P001 – P017: Pluripotency and embryonic stem cells
P018 – P038: Programing and Reprograming
P039 – P061: Stem cells in development
P062 – P072: Somatic stem cells
(posters will be displayed in front of room K 1+2)
P073 – P097: Hematopoietic stem cells

Even numbers: please present your poster from 16:15 – 17:15
Uneven numbers: please present your poster from 17:15 – 18:15

18:15 – 19:15 Dinner
19:15 – 20:45
GSCN General Membership Meeting
20:45 - 21:30


Tuesday, November 4th

Concurrent scientific working group session II
Lecture hall:
Stem cells in disease modeling and drug development (chair: Oliver Brüstle/Karl-Ludwig Laugwitz)
09:00 – 09:20
The use of stem cells in disease modeling and drug development - Overview
Oliver Brüstle; Institute of Reconstructive Neurobiology, Bonn
09:20 – 09:35 T18 - Probing mitochondrial DNA disorders using iPSC-derived neural progenitors
Alessandro Prigione; Max Delbrück Center, Berlin
09:35 – 09:50  T19 - Modeling Dravet syndrome in iPS cell-derived neurons
Matthias Hebisch; Institute of Reconstructive Neurobiology, Bonn
09:50 – 10:05  T20 - The functionality of stem cell derived neurons: How to define it?
Sebastian Illes; Inst. of Molecular Reg. Medicine, Salzburg, Austria
10:05 – 10:20  T21 - Modeling and pharmacological rescue of ion channel diseases enabled by improved cardiac induction of human pluripotent stem cells in 2D and 3D formats
Boris Greber; Max Plank Institute for Molecular Biomedicine, Münster
10:20 – 10:30 Group discussion
Romm K 1+2: Pluripotency and embryonic stem cells (chair: James Adjaye/Mathias Treier)
09:00 – 09:20 Pluripotency and embryonic stem cells: Introduction and Overview
James Adjaye; University Hospital of Düsseldorf
09:20 – 09:35 T22 - Primate-specific endogenous retrovirus driven transcription defines naïve-like stem cells
Jichang Wang; Max Delbrück Center, Berlin
09:35 – 09:50 T23 - A novel lncRNA-protein interaction characterizes mouse embryonic stem cell fate
Debojyoti Chakraborty; Dresden University of Technology 
09:50 – 10:05 T24 - NANOG and CDX2 Pattern distinct subtypes of human mesoderm during Exit from Pluripotency
Sasha Mendjan; Cambridge Stem Cell Institute, United Kingdom
10:05 – 10:20 T25 - Insights from the streak: identification of novel genes associated with germ-layer formation and mesendoderm differentiation
Cantas Alev; RIKEN Center for Developmental Biology, Kobe, Japan 
10:20 – 10:30 Group discussion 
ZMBH (ground floor): Stem cells in development (chair: Jan Lohmann/Francesca Spagnoli)
09:00 – 09:15 Stem cells in development – An overview
Jan Lohmann; Centre for Organismal Studies Heidelberg 
09:15 – 09:30 T26 - Tet-dependent processing of 5-methylcytosine protects DNA methylation canyons against hypermethylation
Achim Breiling; German Cancer Research Center, Heidelberg
09:30 – 09:45 T27 - PIEZO2 is required for mechanotransduction in human ES-cell-derived touch receptors
Katrin Schrenk-Siemens; University of Heidelberg 
09:45 – 10:00 T28 - Transcriptional and epigenetic dynamics underlying cell lineage commitment
Filippo M. Cernilogar; Ludwig Maximilian University, Munich 
10:00 – 10:15 T29 - The histone 3 lysine 4 methyltransferase Mll2 primes the Nxt2 promoter for neural differentiation
Katrin Neumann; Dresden University of Technology
10:15 – 10:30 T30 - Signals from the injury niche increase fate potential of adult neural stem cells
Enric Llorens Bobadilla; German Cancer Research Center, Heidelberg 
10:30 – 11:15
Coffee break/industry exhibition
Industry session: "Technologies from GSCN industry partners"
Lecture hall:
Main supporters
11:15 – 11:20  Introduction (Andreas Trumpp)
11:20 – 11:50  C01 - High throughput screening using iPSC-based models
Jared Sterneckert; CRT Dresden, representing PeproTech GmbH
11:50 – 12:20  C02 - Controlling expansion and cardiomyogenic differentiation of human pluripotent stem cells in scalable suspension culture
Robert Zweigerdt; MH Hannover, representing Eppendorf AG
12:20 – 12:50
C03 - Raw materials in the manufacture of advanced therapies medicinal products: Quality attributes and quality assurance
Bernd Leistler; CellGenix GmbH
Room K 1+2:
11:15 – 11:20  Introduction (Michael Cross
11:20 – 11:50  C04 – Efficient Neural and Cardiac Differentiation Systems for iPSC
Mohan C. Vemuri; Life Technologies GmbH
11:50 – 12:20  C05 - Cell-based gene delivery leverages conventional immunotherapy for cancer; Treatment of advanced gastrointestinal cancer in a phase I/II trial with modified autologous MSC_apceth_101
Volker Scherhammer; apceth GmbH & Co. KG 
 12:20 – 12:50 C06 - Scalable enzyme-free protocols for the isolation and maintenance of human induced pluripotent stem cells without mechanical colony scraping
Alexandra Blak; STEMCELL Technologies SARL
ZMBH (ground floor):
11:15 – 11:20  Introduction (Torsten Tonn)
11:20 – 11:50  C07 - The future is counting – Digital analysis of RNA, DNA and protein biomarkers
Maik Pruess; NanoString Technologies Germany GmbH
11:50 – 12:20  C08 – Primate iPS cells as tools for evolutionary analyses
Wolfgang Enard; Ludwig Maximillians University, Munich; representing Fluidigm Europe B.V.
12:20 – 12:50 C09 – Building bridges from research to therapy: A roadmap for the successful generation of clinical-grade iPSCs
Thomas Fellner; Lonza Cologne GmbH
12:50 – 14:30
Lunch buffet, industry exhibition and poster viewing 
supported by STEMCELL Technologies SARL
13:15 – 14:15 Room K 1+2: Explaining science and motivating people – Outreach materials for stem cell research (Tobias Cantz/Ira Herrmann
Concurrent strategic working group session A
Lecture hall:
Career development (chairs: Hartmut Geiger/Insa Schröder)
14:30 – 14:45  Careers in industry, Andreas Bosio; Miltenyi GmbH, Berg. Gladbach 
14:45 – 15:00  Careers in science administration, Hella Lichtenberg; DLR Bonn
15:00 – 15:15  Careers in academia, Hartmut Geiger/Insa Schröder 
15:15 – 15:30  Panel discussion
Room K 1+2: Clinical trials and regulatory affairs I (chair: Andreas Kurtz/Torsten Tonn/Hans-Dieter Volk)
supported by apceth GmbH & Co. KG 
14:30 – 14:50  Development of iPS cell-based cardiac therapy
Ulrich Martin, MH Hannover 
14:50 – 15:10  Regulatory challenges of stem cell-based medicinal products
Egbert Flory; Paul Ehrlich Institute, Langen 
15:10 – 15:30  Group/panel discussion
ZMBH (ground floor): Large scale banking of human pluripotent stem cells - workshop (chair: Andreas Kurtz/Joana Namorado
14:30 – 14:45  Biomedical applications of iPS cell technology
Angel Raya; CMRB Barcelona 
14:45 – 15:00  The need for large-scale iPSC collections - a pharma perspective
Alex Gutteridge; Pfizer 
15:00 – 15:15  Delivery of human pluripotent stem cells for therapy: Phase IV of the UK Stem Cell Bank Project
Lyn Healy; UK Stem Cell Bank, South Mimms, U.K. 
15:15 – 15:30  The relaunch of the human pluripotent stem cell registry (hESCreg)
Andreas Kurtz; BCRT Berlin
15:30 – 15:45
Short break
Concurrent strategic working group session B
Lecture hall:
Stem cell technologies (chair: Andreas Bosio/Frank Emmrich)
15:45 – 15:50  Introduction: Andreas Bosio, Miltenyi GmbH, Berg. Gladbach 
15:50 – 16:05  Methods of genetic engineering
Claudio Mussolino; University of Freiburg 
16:05 – 16:20  Reprogramming technologies
Micha Drukker; Helmholtz Center Munich 
16:20 – 16:35  Methods of laser cell printing
Boris Chichkov; Laser Center Hannover (LZH) 
16:35 – 16:45  Group/panel discussions
Room K 1+2:  Clinical trials and regulatory affairs II (chair: Andreas Kurtz/Torsten Tonn/Hans-Dieter Volk 
15:45 – 16:05  Placenta expanded mesenchymal (PLX) cells– preclinical data for preparing clinical trials
Lena Pinzur; PluriStem Therapeutics Inc., Haifa, Israel 
16:05 – 16:25  PLX cells - from preclinical to clinical studies – what did we learn so far from biomarker studies?
Hans-Dieter Volk; Berlin-Brandenburg Center for Reg. Therapies (BCRT) 
16:25 – 16:45  Panel discussions 
ZMBH (ground floor):   Funding opportunities for young and advanced scientists (chair: Hartmut Geiger/Albrecht Müller) 
15:45 – 16:30  Funding opportunities of the DFG for stem cell scientists at various career stages
Eckard Picht; German Research Foundation (DFG), Bonn 
16:30 – 16:45  Group Discussion
16:45 – 17:15 Coffee break and industry exhibition
16:46 – 17:45 DKFZ Mensa: Meet-the-expert lunch: Stem cell technologies – genetic engineering (Claudio Mussolino) limited to 10 registered participants
17:15 – 19:15  Poster session II: P098 – P187
(posters will be displayed in the tent)
P098 – P129: Stem cells in regenerative therapies
P130 – P161: Stem cells in disease modeling and drug development
(posters will be displayed in front of room K 1+2)
P162 – P178: Stem cells in disease: Cancer stem cells
P179 – P187: Computational stem cell biology

Even numbers: please present your poster from 17:15 – 18:15
Uneven numbers: please present your poster from 18:15 – 19:15 
19:15 – 20:00 Free bus shuttle to networking evening (busses will depart from the DKFZ main entrance)
20:00 – 01:00
Networking evening with dinner buffet at Schlosshotel “Molkenkur”
Klingenteichstr. 31, 69117 Heidelberg (
(Opening: Oliver Brüstle) (included in the registration fee)
supported by CellGenix GmbH


Wednesday, November 5th

Concurrent scientific working group session III 
Lecture hall:
Hematopoietic stem cells (chair: Anthony Ho/Claudia Waskow)
09:00 – 09:20  Introduction “Hematopoietic stem cells”
Claudia Waskow; Technical University Dresden 
09:20 – 09:35  T31 - Stroma-derived osteopontin regulates hematopoietic stem and progenitor cells function upon aging
Novella Guidi; University of Ulm 
09:35 – 09:50  T32 - Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis
Daniel Klimmeck; German Cancer Research Center, Heidelberg 
09:50 – 10:05  T33 - Kit deficiency regulates stable human hematopoietic stem cell engraftment in mice
Susann Rahmig; Technical University Dresden 
10:05 – 10:20  T34 - STAT5-regulated miRNA193b controls hematopoietic stem and progenitor cell expansion by fine tuning cytokine signaling
Nadine Hätscher; University Hospital Frankfurt 
10:20 – 10:30  Group discussion 
Room K 1+2:  Programming and reprogramming (chair: Micha Drukker/Frank Edenhofer) 
09:00 – 09:15  Introduction to re-programming
Frank Edenhofer; University of Würzburg 
09:15 – 09:30  T35 - Selective gene delivery into human iPS cells based on CD30-targeted lentiviral vectors
Thorsten Friedel; Paul Ehrlich Institute, Langen 
09:30 – 09:45  T36 - Generation of iPS cells from young vs. aged cell sources – influence of donor age on reprogramming efficiency and genetic stability of iPS clones
Katarzyna Osetek; LEBAO/Hannover Medical School 
09:45 – 10:00  T37 - Mesenchymal stem cells derived from iPS cells from aged individuals acquire fetal characteristics
Lucas Spitzhorn; University Hospital of Düsseldorf 
10:00 – 10:15  T38 - TRIM32, a dual player regulating the entry and exit from pluripotency
Lamia'a Bahnassawy; University of Luxembourg 
10:15 – 10:30  T39 - Robust generation of cardiomyocytes from human iPS cells requires precise modulation of Bmp and Wnt signaling
Asifiqbal Kadari; Julius Maximilians University, Würzburg 
DKFZ SR 4th floor:   Stem cells in regenerative therapies II (chair: Michael Cross/Frank H2.04.073 Emmrich)
The meeting point for this session is at the registration desk! 
09:00 – 09:15  Introduction to session II stem cells in regenerative therapies
Michael Cross; University of Leipzig 
09:15 – 09:30  T40 - Efficient generation of functionally defined iPSC-derived human neural stem/progenitor cells and oligodendrocytes
Giacomo Frati; San Raffaele Scientific Institute, Milan, Italy 
09:30 – 09:45  T41 - Aging affects the mesenchymal stem cell derived oligodendrogenic / remyelination activities: implication for a potential therapy of multiple sclerosis
Francisco J. Rivera; Paracelsus Medical University, Salzburg, Austria 
09:45 – 10:00  T42 - The european project REBORNE: Multipotent mesenchymal stromal cells and biomaterial for bone healing
Alexander Erle; Ulm University Hospital 
10:00 – 10:15  T43 - Identification, isolation and targeted inhibition of a fibroblast lineage responsible for scarring and cancer stroma
Yuval Rinkevich; Stanford Institute for Stem Cell Biology and Regenerative Medicine, U.S.A. 
10:15 – 10:30  T44 - Proofing the (Un)Proven: Proven or approved stem cell therapies – that is the question
Bianca Büchner; Center for Ethics and Law in the Life Sciences (CELLS), Hannover
10:30 – 11:00  Coffee break and industry exhibition
Concurrent Workshops
Lecture hall:  Clinical relevance of animal models in stem cell research and regenerative medicine (chair: Georg Duda/Frank Emmrich)
(Workshop of the ‘Regenerative Medicine Initiative Germany (RMIG)’) 
11:00 – 11:20  Introduction: Animal models in research for regenerative medicine
Axel Haverich; Rebirth/Hannover Medical School 
11:20 – 11:30  Cell transplantation into pre-clinical models of retinal degeneration
Marius Ader; Center for Regenerative Therapies Dresden 
11:30 – 11:40  Medical devices and the application of stem cells
Konrad Kohler; zrm, Tübingen University Hospital 
11:40 – 11:50   Regenerative medicine for an aging society: How relevant are our current animal models?
Georg Duda; BCRT Berlin 
11:50 – 12:00  Heterogeneity, age, comorbidities and the translational failure – can we do better in projecting from preclinical stem cell studies to clinical trials?
Johannes Boltze; TRM Leipzig 
12:00 – 12:10  Hurdles for clinical translation of regenerative stem cell therapy – lessons learned from the cardiac Phase III PERFECT multicenter trial
Gustav Steinhoff; RTC Rostock
12:10 – 12:30  Panel discussion 
Room K 1+2:  Big pharma and the stem cell field – matching expectations? (organizer: Oliver Brüstle/Ira Herrmann)
(Workshop of the Stem Cell Network North Rhine Westphalia)

Oliver Brüstle; LIFE & BRAIN GmbH, Bonn 
Ralf Heilker; Boehringer Ingelheim Pharma GmbH & Co. KG, Div. Research Germany
Jörg Hüser; Bayer Pharma AG, Lead Discovery Wuppertal 
Bert Klebl; Lead Discovery Center GmbH, Dortmund
Moderation: Ira Herrmann; Stem Cell Network NRW, Düsseldorf 
ZMBH (ground floor):  Proceedings of the German Society for Stem Cell Research (GSZ e.V.) (chair: Jürgen Hescheler)
Speaker: Jürgen Rohwedel; Lübeck, Robert David; Rostock; Tanja Waldmann; Konstanz, Bernd Denecke; RWTH Aachen 
12:30 – 12:45 Short break
12:45 – 13:30  Keynote lecture III
K3 - Molecular and cellular regulation of muscle stem cells during development and regeneration
Shahragim Tajbakhsh; Institute Pasteur, Paris, France
(Chair: Oliver Brüstle) 
13:30 – 15:00
Lunch buffet/industry exhibition
supported by Nanostring Technologies Germany GmbH
13:45 – 14:45  Room K 1+2: Explaining science and motivating people – Outreach materials for stem cell research (Tobias Cantz/Ira Herrmann) 
13:45 – 14:45  DKFZ Mensa: Meet-the-expert lunch: Stem cell technologies – laser printing (Boris Chichkov) and - reprogramming technologies (Micha Drukker) limited to 10 registered participants each
Closing ceremony
15:00 – 15:15  Poster award ceremonies and announcement of industry quiz winners (Daniel Besser; GSCN)
supported by PeproTech GmbH 
15:15 – 15:30  Outlook and closing remarks
Incoming president: Thomas Braun 
15:30 – 16:15  Keynote lecture IV – Joined session with the 6th BMBF symposium – Adult neural stem cells (chair: Magdalena Götz/Ana Martin-Villalba)
K4 - Modeling human brain development and disease in 3D culture
Jürgen Knoblich; Institute of Molecular Biotechnology (IMBA) 
Vienna, Austria
supported by Life Technologies GmbH
16:15 – 17:00  K5 - Adult hippocampal neurogenesis: What are new neurons good for? And what is good for them?
Amelia Eisch; UT Southwestern, Dallas, U.S.A. 
17:00 – 17:45  K6 - A mechanism for the segregation of age in mammalian neural stem cells
Sebastian Jessberger; University of Zurich, Switzerland 
17:45 – 18:30  Coffee break and poster session GSCN satellite event
End of GSCN conference 2014

18:30 – 20:00  Public outreach event of the GSCN in collaboration with the Ernst Schering Foundation and the DKFZ (in German)
Stammzellen als Chance – Realität und Perspektiven
Podiumsdiskussion zur aktuellen Forschung in Labor und Klinik

Magdalena Götz (LMU München), Anthony Ho (Uni. Heidelberg), Andreas Trumpp (DKFZ)
Moderation: Stefanie Seltmann (DKFZ) 
20:00 – 21:00 Reception public outreach event 
November 6th, 2014 - GSCN Satellite Event: 6th BMBF Symposium – Adult neural stem cells
The program of the satellite event is available at the reception desk.