Program

Monday, November 3rd

11:00 – 12:00	Registration and light lunch
	Opening
12:00 - 12:05	Welcome to the German Cancer Research Center (DKFZ) Ottmar Wiestler (Chairman and Scientific Director, DKFZ)
12:05 - 12:15	Andreas Trumpp (Acting President, GSCN)
12:15 - 12:30	Opening remarks Bärbel Brumme-Bothe (Department Head "Life Sciences", BMBF)
12:30 – 13:15	Keynote lecture I Cancer Stem Cells Eduard Batlle; Institute for Research in Biomedicine Barcelona, Spain (chair: Andreas Trumpp) supported by Eppendorf AG
13:15 – 14:00	Keynote lecture II Myocardial regeneration by ESC-derived cardiac progenitors Philippe Menasché; University of Paris Descartes, Paris, France (chair: Ulrich Martin)
14:00 – 14:30	Coffee break and industry exhibition
Concurrent scientific working group session I
Lecture hall:	Stem cells in regenerative therapies I (chair: Ulrich Martin/Hans-Dieter Volk)
14:30 – 14:50	Stem cells in regenerative therapies – Introduction Ulrich Martin; Rebirth/Hannover Medical School
14:50 – 15:05	T01 – Intranasal delivery of migratory neural stem/progenitor cells: A non-invasive passage to therapeutically target intracerebral brain tumors Nils Ole Schmidt; University Medical Center, Hamburg-Eppendorf
15:05 – 15:20	T02 - MicroRNA-181a promotes human neuronal differentiation by down-regulating genes involved in neural stem cell maintenance Laura Stappert; Institute of Reconstructive Neurobiology, Bonn
15:20 – 15:35	T03 - Pulmonary transplantation of multipotent- or pluripotent-stem cell derived macrophages as a novel treatment option for pulmonary alveolar proteinosis Nico Lachmann; Hannover Medical School
15:35 – 15:50	T04 - Human iPSC-derived MSC-like progenitor cells: functional differences from primary MSCs affecting their use in cartilage regenerative medicine Solvig Diederichs; University Hospital Heidelberg
15:50 – 16:00	Group discussion
Room K1:	Stem cells in disease: cancer stem cells (chair: Thomas Brabletz/ Andreas Trumpp)
14:30 – 14:50	Concepts of cancer stem cells – Introduction Andreas Trumpp; German Cancer Research Center, Heidelberg
14:50 – 15:05	T05 - Shp2 Signaling is essential to the suppression of senescence in mammary gland cancer stem cells in mice Linxiang Lan; Max Delbrück Center, Berlin
15:05 – 15:20	T06 - Humanization of mouse models for human breast cancer using mesenchymal stem cells Maxine Silvestrov; Experimental Pharmacology & Oncology (EPO) GmbH, Berlin
15:20 – 15:35	T07 - Targeting the kinome to induce differentiation in human breast cancer stem cells Jochen Maurer; University Medical Center Freiburg
15:35 – 15:50	T08 - CD151+ cells drive tumor-initiation, hierarchical growth and proliferation-associated signaling in patient-derived models of serous ovarian cancer Franziska Zickgraf; German Cancer Research Center, Heidelberg
15:50 – 16:00	Group discussion
Room K 2:	Computational stem cell biology (chair: Georg Fuellen/Ingo Roeder)
14:30 – 14:45	Computational stem cell biology – Overview and introduction Ingo Roeder; Dresden University of Technology
14:45 – 14:55	T09 - What makes stem cells move? Studying stem cell migration in vitro (back-to-back presentation with T10) Michael Ansorge; Leipzig University
14:44 – 15:05	T10 - What makes stem cells move? Studying stem cell migration in silico (back-to-back presentation with T09) Axel Krinner; Dresden University of Technology
15:05 – 15:20	T11 - Characterizing transcriptional cell-to-cell heterogeneities during stem cell differentiation Fabian Theis; Helmholtz Center Munich
15:20 – 15:35	T12 - A network-based strategy to direct cell fate determination Antonio del Sol; Luxembourg Center for Systems Biomedicine
15:35 – 15:50	T13 - Computational identification of pluripotency networks Maryam Nazarieh; Saarland University, Saarbrücken
15:50 – 16:00	Group discussion
ZMBH (ground floor):	Somatic stem cells (chair: Thomas Braun/Ana Martin-Villalba)
14:30 – 14:50	Studies on somatic stem cells – An introduction Thomas Braun; Max Planck Inst. f. Heart and Lung Res., Bad Nauheim
14:40 – 15:05	T14 - The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs Sarah Nicklas; Luxembourg Center for Systems Biomedicine
15:05 – 15:20	T15 - Angiogenesis controls neural stem cell expansion by regulating tissue oxygenation and HIF signaling Christian Lange; VIB KU Leuven Campus, Belgium
15:20 – 15:35	T16 - Regulation of asymmetric/symmetric stem cell division in human epidermis Katharina Nöske; German Cancer Research Center, Heidelberg
15:35 – 15:50	T17 - Clonal heterogeneity within the exocrine pancreas Damian Wollny; German Cancer Research Center, Heidelberg
15:50 – 16:00	Group discussion
16:00 – 16:15	Coffee break/industry exhibition
16:15 – 18:15	Poster session I: P001 – P097 supported by Fluidigm Europe B.V.
	(posters will be displayed in the tent) P001 – P017: Pluripotency and embryonic stem cells P018 – P038: Programing and Reprograming P039 – P061: Stem cells in development P062 – P072: Somatic stem cells (posters will be displayed in front of room K 1+2) P073 – P097: Hematopoietic stem cells Even numbers: please present your poster from 16:15 – 17:15 Uneven numbers: please present your poster from 17:15 – 18:15
18:15 – 19:15	Dinner
19:15 – 20:45	GSCN General Membership Meeting
20:45 - 21:30	Get-together

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Tuesday, November 4th

Concurrent scientific working group session II
Lecture hall:	Stem cells in disease modeling and drug development (chair: Oliver Brüstle/Karl-Ludwig Laugwitz)
09:00 – 09:20	The use of stem cells in disease modeling and drug development - Overview Oliver Brüstle; Institute of Reconstructive Neurobiology, Bonn
09:20 – 09:35	T18 - Probing mitochondrial DNA disorders using iPSC-derived neural progenitors Alessandro Prigione; Max Delbrück Center, Berlin
09:35 – 09:50	T19 - Modeling Dravet syndrome in iPS cell-derived neurons Matthias Hebisch; Institute of Reconstructive Neurobiology, Bonn
09:50 – 10:05	T20 - The functionality of stem cell derived neurons: How to define it? Sebastian Illes; Inst. of Molecular Reg. Medicine, Salzburg, Austria
10:05 – 10:20	T21 - Modeling and pharmacological rescue of ion channel diseases enabled by improved cardiac induction of human pluripotent stem cells in 2D and 3D formats Boris Greber; Max Plank Institute for Molecular Biomedicine, Münster
10:20 – 10:30	Group discussion
Romm K 1+2:	Pluripotency and embryonic stem cells (chair: James Adjaye/Mathias Treier)
09:00 – 09:20	Pluripotency and embryonic stem cells: Introduction and Overview James Adjaye; University Hospital of Düsseldorf
09:20 – 09:35	T22 - Primate-specific endogenous retrovirus driven transcription defines naïve-like stem cells Jichang Wang; Max Delbrück Center, Berlin
09:35 – 09:50	T23 - A novel lncRNA-protein interaction characterizes mouse embryonic stem cell fate Debojyoti Chakraborty; Dresden University of Technology
09:50 – 10:05	T24 - NANOG and CDX2 Pattern distinct subtypes of human mesoderm during Exit from Pluripotency Sasha Mendjan; Cambridge Stem Cell Institute, United Kingdom
10:05 – 10:20	T25 - Insights from the streak: identification of novel genes associated with germ-layer formation and mesendoderm differentiation Cantas Alev; RIKEN Center for Developmental Biology, Kobe, Japan
10:20 – 10:30	Group discussion
ZMBH (ground floor):	Stem cells in development (chair: Jan Lohmann/Francesca Spagnoli)
09:00 – 09:15	Stem cells in development – An overview Jan Lohmann; Centre for Organismal Studies Heidelberg
09:15 – 09:30	T26 - Tet-dependent processing of 5-methylcytosine protects DNA methylation canyons against hypermethylation Achim Breiling; German Cancer Research Center, Heidelberg
09:30 – 09:45	T27 - PIEZO2 is required for mechanotransduction in human ES-cell-derived touch receptors Katrin Schrenk-Siemens; University of Heidelberg
09:45 – 10:00	T28 - Transcriptional and epigenetic dynamics underlying cell lineage commitment Filippo M. Cernilogar; Ludwig Maximilian University, Munich
10:00 – 10:15	T29 - The histone 3 lysine 4 methyltransferase Mll2 primes the Nxt2 promoter for neural differentiation Katrin Neumann; Dresden University of Technology
10:15 – 10:30	T30 - Signals from the injury niche increase fate potential of adult neural stem cells Enric Llorens Bobadilla; German Cancer Research Center, Heidelberg
10:30 – 11:15	Coffee break/industry exhibition
Industry session: "Technologies from GSCN industry partners"
Lecture hall:	Main supporters
11:15 – 11:20	Introduction (Andreas Trumpp)
11:20 – 11:50	C01 - High throughput screening using iPSC-based models Jared Sterneckert; CRT Dresden, representing PeproTech GmbH
11:50 – 12:20	C02 - Controlling expansion and cardiomyogenic differentiation of human pluripotent stem cells in scalable suspension culture Robert Zweigerdt; MH Hannover, representing Eppendorf AG
12:20 – 12:50	C03 - Raw materials in the manufacture of advanced therapies medicinal products: Quality attributes and quality assurance Bernd Leistler; CellGenix GmbH
Room K 1+2:	Supporters
11:15 – 11:20	Introduction (Michael Cross)
11:20 – 11:50	C04 – Efficient Neural and Cardiac Differentiation Systems for iPSC Mohan C. Vemuri; Life Technologies GmbH
11:50 – 12:20	C05 - Cell-based gene delivery leverages conventional immunotherapy for cancer; Treatment of advanced gastrointestinal cancer in a phase I/II trial with modified autologous MSC_apceth_101 Volker Scherhammer; apceth GmbH & Co. KG
12:20 – 12:50	C06 - Scalable enzyme-free protocols for the isolation and maintenance of human induced pluripotent stem cells without mechanical colony scraping Alexandra Blak; STEMCELL Technologies SARL
ZMBH (ground floor):	Supporters
11:15 – 11:20	Introduction (Torsten Tonn)
11:20 – 11:50	C07 - The future is counting – Digital analysis of RNA, DNA and protein biomarkers Maik Pruess; NanoString Technologies Germany GmbH
11:50 – 12:20	C08 – Primate iPS cells as tools for evolutionary analyses Wolfgang Enard; Ludwig Maximillians University, Munich; representing Fluidigm Europe B.V.
12:20 – 12:50	C09 – Building bridges from research to therapy: A roadmap for the successful generation of clinical-grade iPSCs Thomas Fellner; Lonza Cologne GmbH
12:50 – 14:30	Lunch buffet, industry exhibition and poster viewing supported by STEMCELL Technologies SARL
13:15 – 14:15	Room K 1+2: Explaining science and motivating people – Outreach materials for stem cell research (Tobias Cantz/Ira Herrmann)
Concurrent strategic working group session A
Lecture hall:	Career development (chairs: Hartmut Geiger/Insa Schröder)
14:30 – 14:45	Careers in industry, Andreas Bosio; Miltenyi GmbH, Berg. Gladbach
14:45 – 15:00	Careers in science administration, Hella Lichtenberg; DLR Bonn
15:00 – 15:15	Careers in academia, Hartmut Geiger/Insa Schröder
15:15 – 15:30	Panel discussion
Room K 1+2:	Clinical trials and regulatory affairs I (chair: Andreas Kurtz/Torsten Tonn/Hans-Dieter Volk) supported by apceth GmbH & Co. KG
14:30 – 14:50	Development of iPS cell-based cardiac therapy Ulrich Martin, MH Hannover
14:50 – 15:10	Regulatory challenges of stem cell-based medicinal products Egbert Flory; Paul Ehrlich Institute, Langen
15:10 – 15:30	Group/panel discussion
ZMBH (ground floor):	Large scale banking of human pluripotent stem cells - workshop (chair: Andreas Kurtz/Joana Namorado)
14:30 – 14:45	Biomedical applications of iPS cell technology Angel Raya; CMRB Barcelona
14:45 – 15:00	The need for large-scale iPSC collections - a pharma perspective Alex Gutteridge; Pfizer
15:00 – 15:15	Delivery of human pluripotent stem cells for therapy: Phase IV of the UK Stem Cell Bank Project Lyn Healy; UK Stem Cell Bank, South Mimms, U.K.
15:15 – 15:30	The relaunch of the human pluripotent stem cell registry (hESCreg) Andreas Kurtz; BCRT Berlin
15:30 – 15:45	Short break
Concurrent strategic working group session B
Lecture hall:	Stem cell technologies (chair: Andreas Bosio/Frank Emmrich)
15:45 – 15:50	Introduction: Andreas Bosio, Miltenyi GmbH, Berg. Gladbach
15:50 – 16:05	Methods of genetic engineering Claudio Mussolino; University of Freiburg
16:05 – 16:20	Reprogramming technologies Micha Drukker; Helmholtz Center Munich
16:20 – 16:35	Methods of laser cell printing Boris Chichkov; Laser Center Hannover (LZH)
16:35 – 16:45	Group/panel discussions
Room K 1+2:	Clinical trials and regulatory affairs II (chair: Andreas Kurtz/Torsten Tonn/Hans-Dieter Volk)
15:45 – 16:05	Placenta expanded mesenchymal (PLX) cells– preclinical data for preparing clinical trials Lena Pinzur; PluriStem Therapeutics Inc., Haifa, Israel
16:05 – 16:25	PLX cells - from preclinical to clinical studies – what did we learn so far from biomarker studies? Hans-Dieter Volk; Berlin-Brandenburg Center for Reg. Therapies (BCRT)
16:25 – 16:45	Panel discussions
ZMBH (ground floor):	Funding opportunities for young and advanced scientists (chair: Hartmut Geiger/Albrecht Müller)
15:45 – 16:30	Funding opportunities of the DFG for stem cell scientists at various career stages Eckard Picht; German Research Foundation (DFG), Bonn
16:30 – 16:45	Group Discussion
16:45 – 17:15	Coffee break and industry exhibition
16:46 – 17:45	DKFZ Mensa: Meet-the-expert lunch: Stem cell technologies – genetic engineering (Claudio Mussolino) limited to 10 registered participants
17:15 – 19:15	Poster session II: P098 – P187 (posters will be displayed in the tent) P098 – P129: Stem cells in regenerative therapies P130 – P161: Stem cells in disease modeling and drug development (posters will be displayed in front of room K 1+2) P162 – P178: Stem cells in disease: Cancer stem cells P179 – P187: Computational stem cell biology Even numbers: please present your poster from 17:15 – 18:15 Uneven numbers: please present your poster from 18:15 – 19:15
19:15 – 20:00	Free bus shuttle to networking evening (busses will depart from the DKFZ main entrance)
20:00 – 01:00	Networking evening with dinner buffet at Schlosshotel “Molkenkur” Klingenteichstr. 31, 69117 Heidelberg (www.molkenkur.de) (Opening: Oliver Brüstle) (included in the registration fee) supported by CellGenix GmbH

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Wednesday, November 5th

Concurrent scientific working group session III
Lecture hall:	Hematopoietic stem cells (chair: Anthony Ho/Claudia Waskow)
09:00 – 09:20	Introduction “Hematopoietic stem cells” Claudia Waskow; Technical University Dresden
09:20 – 09:35	T31 - Stroma-derived osteopontin regulates hematopoietic stem and progenitor cells function upon aging Novella Guidi; University of Ulm
09:35 – 09:50	T32 - Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis Daniel Klimmeck; German Cancer Research Center, Heidelberg
09:50 – 10:05	T33 - Kit deficiency regulates stable human hematopoietic stem cell engraftment in mice Susann Rahmig; Technical University Dresden
10:05 – 10:20	T34 - STAT5-regulated miRNA193b controls hematopoietic stem and progenitor cell expansion by fine tuning cytokine signaling Nadine Hätscher; University Hospital Frankfurt
10:20 – 10:30	Group discussion
Room K 1+2:	Programming and reprogramming (chair: Micha Drukker/Frank Edenhofer)
09:00 – 09:15	Introduction to re-programming Frank Edenhofer; University of Würzburg
09:15 – 09:30	T35 - Selective gene delivery into human iPS cells based on CD30-targeted lentiviral vectors Thorsten Friedel; Paul Ehrlich Institute, Langen
09:30 – 09:45	T36 - Generation of iPS cells from young vs. aged cell sources – influence of donor age on reprogramming efficiency and genetic stability of iPS clones Katarzyna Osetek; LEBAO/Hannover Medical School
09:45 – 10:00	T37 - Mesenchymal stem cells derived from iPS cells from aged individuals acquire fetal characteristics Lucas Spitzhorn; University Hospital of Düsseldorf
10:00 – 10:15	T38 - TRIM32, a dual player regulating the entry and exit from pluripotency Lamia'a Bahnassawy; University of Luxembourg
10:15 – 10:30	T39 - Robust generation of cardiomyocytes from human iPS cells requires precise modulation of Bmp and Wnt signaling Asifiqbal Kadari; Julius Maximilians University, Würzburg
DKFZ SR 4th floor:	Stem cells in regenerative therapies II (chair: Michael Cross/Frank H2.04.073 Emmrich) The meeting point for this session is at the registration desk!
09:00 – 09:15	Introduction to session II stem cells in regenerative therapies Michael Cross; University of Leipzig
09:15 – 09:30	T40 - Efficient generation of functionally defined iPSC-derived human neural stem/progenitor cells and oligodendrocytes Giacomo Frati; San Raffaele Scientific Institute, Milan, Italy
09:30 – 09:45	T41 - Aging affects the mesenchymal stem cell derived oligodendrogenic / remyelination activities: implication for a potential therapy of multiple sclerosis Francisco J. Rivera; Paracelsus Medical University, Salzburg, Austria
09:45 – 10:00	T42 - The european project REBORNE: Multipotent mesenchymal stromal cells and biomaterial for bone healing Alexander Erle; Ulm University Hospital
10:00 – 10:15	T43 - Identification, isolation and targeted inhibition of a fibroblast lineage responsible for scarring and cancer stroma Yuval Rinkevich; Stanford Institute for Stem Cell Biology and Regenerative Medicine, U.S.A.
10:15 – 10:30	T44 - Proofing the (Un)Proven: Proven or approved stem cell therapies – that is the question Bianca Büchner; Center for Ethics and Law in the Life Sciences (CELLS), Hannover
10:30 – 11:00	Coffee break and industry exhibition
Concurrent Workshops
Lecture hall:	Clinical relevance of animal models in stem cell research and regenerative medicine (chair: Georg Duda/Frank Emmrich) (Workshop of the ‘Regenerative Medicine Initiative Germany (RMIG)’)
11:00 – 11:20	Introduction: Animal models in research for regenerative medicine Axel Haverich; Rebirth/Hannover Medical School
11:20 – 11:30	Cell transplantation into pre-clinical models of retinal degeneration Marius Ader; Center for Regenerative Therapies Dresden
11:30 – 11:40	Medical devices and the application of stem cells Konrad Kohler; zrm, Tübingen University Hospital
11:40 – 11:50	Regenerative medicine for an aging society: How relevant are our current animal models? Georg Duda; BCRT Berlin
11:50 – 12:00	Heterogeneity, age, comorbidities and the translational failure – can we do better in projecting from preclinical stem cell studies to clinical trials? Johannes Boltze; TRM Leipzig
12:00 – 12:10	Hurdles for clinical translation of regenerative stem cell therapy – lessons learned from the cardiac Phase III PERFECT multicenter trial Gustav Steinhoff; RTC Rostock
12:10 – 12:30	Panel discussion
Room K 1+2:	Big pharma and the stem cell field – matching expectations? (organizer: Oliver Brüstle/Ira Herrmann) (Workshop of the Stem Cell Network North Rhine Westphalia) Panel: Oliver Brüstle; LIFE & BRAIN GmbH, Bonn Ralf Heilker; Boehringer Ingelheim Pharma GmbH & Co. KG, Div. Research Germany Jörg Hüser; Bayer Pharma AG, Lead Discovery Wuppertal Bert Klebl; Lead Discovery Center GmbH, Dortmund Moderation: Ira Herrmann; Stem Cell Network NRW, Düsseldorf
ZMBH (ground floor):	Proceedings of the German Society for Stem Cell Research (GSZ e.V.) (chair: Jürgen Hescheler) Speaker: Jürgen Rohwedel; Lübeck, Robert David; Rostock; Tanja Waldmann; Konstanz, Bernd Denecke; RWTH Aachen
12:30 – 12:45	Short break
12:45 – 13:30	Keynote lecture III K3 - Molecular and cellular regulation of muscle stem cells during development and regeneration Shahragim Tajbakhsh; Institute Pasteur, Paris, France (Chair: Oliver Brüstle)
13:30 – 15:00	Lunch buffet/industry exhibition supported by Nanostring Technologies Germany GmbH
13:45 – 14:45	Room K 1+2: Explaining science and motivating people – Outreach materials for stem cell research (Tobias Cantz/Ira Herrmann)
13:45 – 14:45	DKFZ Mensa: Meet-the-expert lunch: Stem cell technologies – laser printing (Boris Chichkov) and - reprogramming technologies (Micha Drukker) limited to 10 registered participants each
Closing ceremony
15:00 – 15:15	Poster award ceremonies and announcement of industry quiz winners (Daniel Besser; GSCN) supported by PeproTech GmbH
15:15 – 15:30	Outlook and closing remarks Incoming president: Thomas Braun
15:30 – 16:15	Keynote lecture IV – Joined session with the 6th BMBF symposium – Adult neural stem cells (chair: Magdalena Götz/Ana Martin-Villalba) K4 - Modeling human brain development and disease in 3D culture Jürgen Knoblich; Institute of Molecular Biotechnology (IMBA) Vienna, Austria supported by Life Technologies GmbH
16:15 – 17:00	K5 - Adult hippocampal neurogenesis: What are new neurons good for? And what is good for them? Amelia Eisch; UT Southwestern, Dallas, U.S.A.
17:00 – 17:45	K6 - A mechanism for the segregation of age in mammalian neural stem cells Sebastian Jessberger; University of Zurich, Switzerland
17:45 – 18:30	Coffee break and poster session GSCN satellite event
End of GSCN conference 2014

Announcements:
18:30 – 20:00	Public outreach event of the GSCN in collaboration with the Ernst Schering Foundation and the DKFZ (in German) Stammzellen als Chance – Realität und Perspektiven Podiumsdiskussion zur aktuellen Forschung in Labor und Klinik Panel: Magdalena Götz (LMU München), Anthony Ho (Uni. Heidelberg), Andreas Trumpp (DKFZ) Moderation: Stefanie Seltmann (DKFZ)
20:00 – 21:00	Reception public outreach event
and
November 6th, 2014 - GSCN Satellite Event: 6th BMBF Symposium – Adult neural stem cells The program of the satellite event is available at the reception desk.

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Program

Monday, November 3rd

Tuesday, November 4th

Wednesday, November 5th

Supporters